Haver Mary Claire, Locksmith Gregory J, Emmet Emily
Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0587, USA.
Am J Obstet Gynecol. 2003 May;188(5):1189-91. doi: 10.1067/mob.2003.311.
Our purpose was to determine whether a history of irregular menses predicts gestational diabetes mellitus independently of traditional risk factors.
We analyzed demographic characteristics, body mass index, and menstrual history of 85 pregnant women with gestational diabetes mellitus and compared them with 85 systematically selected control subjects who were matched for age, race, and delivery year. Subjects with pregestational diabetes mellitus, previous gestational diabetes mellitus, family history of diabetes mellitus, weight >200 pounds, previous macrosomic infants, or previous stillbirth were excluded.
Demographic characteristics between case and control groups were similar. Mean body mass index was higher among cases (26.5 kg/m(2)) versus control subjects (24.5 kg/m(2), P =.004). Irregular cycles were more prevalent in the cases (24% vs 7%, P =.006). With the use of body mass index as a stratification factor, menstrual irregularity maintained a strong association with gestational diabetes mellitus (P =.014).
A history of irregular menstrual cycles was a significant independent predictor of gestational diabetes mellitus. If selective screening is implemented for gestational diabetes mellitus, such history should be considered in the decision of whom to test.
我们的目的是确定月经不规律史是否能独立于传统危险因素预测妊娠期糖尿病。
我们分析了85例妊娠期糖尿病孕妇的人口统计学特征、体重指数和月经史，并将其与85例按年龄、种族和分娩年份匹配的系统选择的对照受试者进行比较。排除孕前糖尿病、既往妊娠期糖尿病、糖尿病家族史、体重>200磅、既往巨大儿或既往死产的受试者。
病例组和对照组的人口统计学特征相似。病例组的平均体重指数（26.5kg/m²）高于对照组（24.5kg/m²，P=0.004）。月经周期不规律在病例组中更为常见（24%对7%，P=0.006）。以体重指数作为分层因素，月经不规律与妊娠期糖尿病仍有很强的相关性（P=0.014）。
月经周期不规律史是妊娠期糖尿病的一个重要独立预测因素。如果对妊娠期糖尿病实施选择性筛查，在决定检测对象时应考虑此类病史。
