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杜氏肌营养不良症且用力肺活量低的患者的脊柱融合术

Spinal fusion in patients with Duchenne's muscular dystrophy and a low forced vital capacity.

作者信息

Marsh A, Edge G, Lehovsky J

机构信息

Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, UK.

出版信息

Eur Spine J. 2003 Oct;12(5):507-12. doi: 10.1007/s00586-003-0545-8. Epub 2003 May 14.

Abstract

Traditionally, spinal fusion has been denied to patients with scoliosis secondary to Duchenne's muscular dystrophy (DMD) when their forced vital capacity (FVC) is less than 30-40% of predicted values (PFVC). The reasons for this decision are a theoretically increased risk of adverse events from a prolonged anaesthetic and extensive surgery. This paper presents a retrospective analysis of 30 patients with DMD scoliosis who underwent posterior spinal fusion at the Royal National Orthopaedic Hospital. Two subgroups of patients were compared: those with more than 30% PFVC (17 patients) and those with less than 30% PVFC (13 patients). One patient in each group required a temporary tracheotomy and there were nine complications in total. The post-operative stay for patients in each group was similar (24 days in the >30% group, 20 days in the <30% group) and the complication rate was comparable with other published series. We conclude that spinal fusion can be offered to patients with DMD even in the presence of a low FVC.

摘要

传统上,当患有杜氏肌营养不良症(DMD)继发脊柱侧弯的患者其用力肺活量(FVC)低于预测值(PFVC)的30%-40%时,不考虑为他们实施脊柱融合术。做出这一决定的原因是理论上长时间麻醉和广泛手术会增加不良事件的风险。本文对在皇家国立骨科医院接受后路脊柱融合术的30例DMD脊柱侧弯患者进行了回顾性分析。比较了两组患者:PFVC超过30%的患者(17例)和PFVC低于30%的患者(13例)。每组各有1例患者需要临时气管切开术,总共出现了9例并发症。每组患者的术后住院时间相似(PFVC>30%组为24天,PFVC<30%组为20天),并发症发生率与其他已发表系列相当。我们得出结论,即使FVC较低,也可以为DMD患者提供脊柱融合术。

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