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活动记录仪在睡眠和昼夜节律研究中的作用。

The role of actigraphy in the study of sleep and circadian rhythms.

作者信息

Ancoli-Israel Sonia, Cole Roger, Alessi Cathy, Chambers Mark, Moorcroft William, Pollak Charles P

机构信息

Department of Psychiatry, University of California, San Diego and Veterans Affairs San Diego Healthcare System, 92161, USA.

出版信息

Sleep. 2003 May 1;26(3):342-92. doi: 10.1093/sleep/26.3.342.

Abstract

In summary, although actigraphy is not as accurate as PSG for determining some sleep measurements, studies are in general agreement that actigraphy, with its ability to record continuously for long time periods, is more reliable than sleep logs which rely on the patients' recall of how many times they woke up or how long they slept during the night and is more reliable than observations which only capture short time periods. Actigraphy can provide information obtainable in no other practical way. It can also have a role in the medical care of patients with sleep disorders. However, it should not be held to the same expectations as polysomnography. Actigraphy is one-dimensional, whereas polysomnography comprises at least 3 distinct types of data (EEG, EOG, EMG), which jointly determine whether a person is asleep or awake. It is therefore doubtful whether actigraphic data will ever be informationally equivalent to the PSG, although progress on hardware and data processing software is continuously being made. Although the 1995 practice parameters paper determined that actigraphy was not appropriate for the diagnosis of sleep disorders, more recent studies suggest that for some disorders, actigraphy may be more practical than PSG. While actigraphy is still not appropriate for the diagnosis of sleep disordered breathing or of periodic limb movements in sleep, it is highly appropriate for examining the sleep variability (i.e., night-to-night variability) in patients with insomnia. Actigraphy is also appropriate for the assessment of and stability of treatment effects of anything from hypnotic drugs to light treatment to CPAP, particularly if assessments are done before and after the start of treatment. A recent independent review of the actigraphy literature by Sadeh and Acebo reached many of these same conclusions. Some of the research studies failed to find relationships between sleep measures and health-related symptoms. The interpretation of these data is also not clear-cut. Is it that the actigraph is not reliable enough to the access the relationship between sleep changes and quality of life measures, or, is it that, in fact, there is no relationship between sleep in that population and quality of life measures? Other studies of sleep disordered breathing, where actigraphy was not used and was not an outcome measure also failed to find any relationship with quality of life. Is it then the actigraph that is not reliable or that the associations just do not exist? The one area where actigraphy can be used for clinical diagnosis is in the evaluation of circadian rhythm disorders. Actigraphy has been shown to be very good for identifying rhythms. Results of actigraphic recordings correlate well with measurements of melatonin and of core body temperature rhythms. Activity records also show sleep disturbance when sleep is attempted at an unfavorable phase of the circadian cycle. Actigraphy therefore would be particularly good for aiding in the diagnosis of delayed or advanced sleep phase syndrome, non-24-hour-sleep syndrome and in the evaluation of sleep disturbances in shift workers. It must be remembered, however, that overt rest-activity rhythms are susceptible to various masking effects, so they may not always show the underlying rhythm of the endogenous circadian pacemaker. In conclusion, the latest set of research articles suggest that in the clinical setting, actigraphy is reliable for evaluating sleep patterns in patients with insomnia, for studying the effect of treatments designed to improve sleep, in the diagnosis of circadian rhythm disorders (including shift work), and in evaluating sleep in individuals who are less likely to tolerate PSG, such as infants and demented elderly. While actigraphy has been used in research studies for many years, up to now, methodological issues had not been systematically addressed in clinical research and practice. Those issues have now been addressed and actigraphy may now be reaching the maturity needed for application in the clinical arena.

摘要

总之,尽管在确定某些睡眠测量值方面,活动记录仪不如多导睡眠图(PSG)准确,但研究普遍认为,活动记录仪能够长时间连续记录,比依赖患者回忆夜间醒来次数或睡眠时间的睡眠日志更可靠,也比仅捕捉短时间段的观察更可靠。活动记录仪能提供通过其他实际方法无法获得的信息。它在睡眠障碍患者的医疗护理中也能发挥作用。然而,不应像对多导睡眠图那样对其抱有同样的期望。活动记录仪是一维的,而多导睡眠图至少包含3种不同类型的数据(脑电图、眼电图、肌电图),这些数据共同决定一个人是睡着还是醒着。因此,尽管硬件和数据处理软件不断取得进展,但活动记录仪的数据在信息上是否能等同于多导睡眠图仍值得怀疑。尽管1995年的实践参数文件确定活动记录仪不适用于睡眠障碍的诊断,但最近的研究表明,对于某些疾病,活动记录仪可能比多导睡眠图更实用。虽然活动记录仪仍不适用于诊断睡眠呼吸障碍或睡眠期周期性肢体运动,但它非常适合用于检查失眠患者的睡眠变异性(即夜间之间的变异性)。活动记录仪也适用于评估从催眠药物到光照疗法再到持续气道正压通气(CPAP)等任何治疗的效果及其稳定性,特别是如果在治疗开始前后进行评估。萨德(Sadeh)和阿塞博(Acebo)最近对活动记录仪文献进行的独立综述得出了许多相同的结论。一些研究未能发现睡眠测量值与健康相关症状之间的关系。这些数据的解释也不明确。是活动记录仪不够可靠,无法揭示睡眠变化与生活质量测量值之间的关系,还是实际上该人群的睡眠与生活质量测量值之间不存在关系?其他关于睡眠呼吸障碍的研究,在未使用活动记录仪且活动记录仪不是结果测量指标的情况下,也未发现与生活质量有任何关系。那么是活动记录仪不可靠,还是这种关联根本不存在呢?活动记录仪可用于临床诊断的一个领域是昼夜节律障碍的评估。活动记录仪已被证明在识别节律方面非常出色。活动记录结果与褪黑素和核心体温节律的测量结果相关性良好。当在昼夜周期的不利阶段尝试睡眠时,活动记录也显示出睡眠障碍。因此,活动记录仪在辅助诊断睡眠时相延迟或提前综合征、非24小时睡眠综合征以及评估轮班工作者的睡眠障碍方面将特别有用。然而,必须记住,明显的休息 - 活动节律容易受到各种掩盖效应的影响,所以它们可能并不总是显示内源性昼夜节律起搏器的潜在节律。总之,最新的一组研究文章表明,在临床环境中,活动记录仪在评估失眠患者的睡眠模式、研究旨在改善睡眠的治疗效果、诊断昼夜节律障碍(包括轮班工作)以及评估不太能耐受多导睡眠图的个体(如婴儿和老年痴呆患者)的睡眠方面是可靠的。虽然活动记录仪已在研究中使用多年,但直到现在,临床研究和实践中尚未系统地解决方法学问题。这些问题现在已经得到解决,活动记录仪现在可能正达到在临床领域应用所需的成熟度。

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