Mollah Abid Hossain, Nahar Nazmun, Siddique Md A, Anwar Kazi Selim, Hassan Tariq, Azam Md Golam
Department of Paediatrics, Dhaka Medical College Hospital, Dhaka 1000, Bangladesh.
J Health Popul Nutr. 2003 Mar;21(1):67-71.
Transfusion-dependent children are more prone to acquiring various transfusion-transmitted infections (TTIs), such as hepatitis B (HBV), hepatitis C (HCV), HIV, and others. Since the magnitude of these infections among thalassaemic children in Bangladesh is not well-known, this study was conducted to assess the prevalence of TTIs among them (who received more than three blood transfusions) compared to their age- and sex-matched controls (non-thalassaemics and those who had never had a transfusion). Seromarkers for HBV, HCV, HDV, Treponema pallidum, and HIV were tested, and the results were analyzed using SPSS/Windows 10.5. Of 259 children studied, 152 (58.69%) were thalassaemic (mean age 6.8 +/- 3.6 years), and 107 were controls (mean age 6.7 +/- 3.53 years). The HBV and HCV-markers were found significantly more often among multi-transfused thalassaemic children than among the controls in terms of HBsAg (13.8% vs 6.5%, p < 0.04), anti-HBc total (39.5% vs 9.4%, p < 0.0001), and anti-HCV (12.5% vs 0.9%, p < 0.0001). HBeAg did not differ (p = 0.82) between the thalassaemics (9.52%) and the controls (14.28%), whereas anti-HBe differed (0% vs 57.14%, p < 0.003). Neither the thalassaemics nor the controls were positive for HDV, HIV, or T. pallidum. Since more thalassaemic children acquired hepatitis B and C infections through multiple blood transfusions, it is recommended that the safe blood-transfusion programme be strengthened and mass vaccination against HBV (even who suffer from HCV) in Bangladesh be undertaken.
依赖输血的儿童更容易感染各种输血传播感染（TTIs），如乙型肝炎（HBV）、丙型肝炎（HCV）、艾滋病毒等。由于孟加拉国地中海贫血儿童中这些感染的严重程度尚不清楚，本研究旨在评估他们（接受过三次以上输血）与年龄和性别匹配的对照组（非地中海贫血患者和从未接受过输血的患者）相比TTIs的患病率。检测了HBV、HCV、HDV、梅毒螺旋体和艾滋病毒的血清标志物，并使用SPSS/Windows 10.5对结果进行分析。在研究的259名儿童中，152名（58.69%）为地中海贫血患者（平均年龄6.8±3.6岁），107名是对照组（平均年龄6.7±3.53岁）。在多次输血的地中海贫血儿童中，HBV和HCV标志物在HBsAg（13.8%对6.5%，p<0.04）、抗-HBc总抗体（39.5%对9.4%，p<0.0001）和抗-HCV（12.5%对0.9%，p<0.0001）方面的检出率明显高于对照组。HBeAg在地中海贫血患者（9.52%）和对照组（14.28%）之间没有差异（p = 0.82），而抗-HBe有差异（0%对57.14%，p<0.003）。地中海贫血患者和对照组的HDV、艾滋病毒或梅毒螺旋体均为阴性。由于更多的地中海贫血儿童通过多次输血感染了乙型肝炎和丙型肝炎，建议加强安全输血计划，并在孟加拉国开展针对HBV的大规模疫苗接种（即使是患有HCV的儿童）。
