Hansen P E B, Wang A G, Stage K B, Kragh-Sorensen P
Department of Psychiatry, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Acta Psychiatr Scand. 2003 Jun;107(6):436-40.
To identify psychopathological predictors for suicide in a population of major depressed Diagnostic Statistical Manual-III (DSM-III) in-patients.
A total of 210 previous participants in multicentre antidepressant drug trials, carried out in a randomized double-blind design, were followed prospectively through a maximum of 10 years. Patients with a drug or alcohol abuse were excluded. The association between suicide and the pretreatment psychopathological profile was analysed using survival statistics.
The suicide rate for non-melancholic depressed patients was significantly higher than for melancholic depressed patients. Comorbid personality disorder was independently associated with an increased suicide rate [relative hazard 3.41(CI: 1.15-10.10)].
The study indicates that the non-melancholic aspect of depression, and especially comorbid personality disorder, is associated with an increased suicidal vulnerability.
确定《精神疾病诊断与统计手册》第三版（DSM-III）中重度抑郁住院患者群体自杀的精神病理学预测因素。
共有210名曾参与多中心抗抑郁药物试验的患者，试验采用随机双盲设计，对其进行了长达10年的前瞻性随访。排除有药物或酒精滥用问题的患者。使用生存统计学方法分析自杀与治疗前精神病理学特征之间的关联。
非忧郁性抑郁症患者的自杀率显著高于忧郁性抑郁症患者。共病的人格障碍与自杀率升高独立相关[相对风险3.41（置信区间：1.15 - 10.10）]。
该研究表明，抑郁症的非忧郁方面，尤其是共病的人格障碍，与自杀易感性增加有关。
