Ashrani Aneel A, Aysola Agnes, Al-Khatib Hani, Nichols William L, Key Nigel S
Department of Medicine, Division of Hematology, Oncology and Transplantation, and Department of Laboratory Medicine and Pathology of the University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Br J Haematol. 2003 May;121(4):639-42. doi: 10.1046/j.1365-2141.2003.04325.x.
Acquired factor X (FX) deficiency is rare, but has been reported in diverse disease states, including systemic amyloidosis and respiratory infections. FX deficiency associated with lupus anticoagulant (LA) and a bleeding diathesis has not been previously reported. We report two patients both of whom presented with a severe bleeding diathesis after a preceding respiratory infection due to isolated FX deficiency associated with a LA. The FX deficiency and LA were transient. We conclude that patients with LA may rarely present with severe acquired FX deficiency. This may be another mechanism whereby patients with antiphospholipid antibodies present with bleeding complications.
获得性因子X（FX）缺乏症较为罕见，但在多种疾病状态下均有报道，包括系统性淀粉样变性和呼吸道感染。此前尚未有与狼疮抗凝物（LA）和出血素质相关的FX缺乏症的报道。我们报告了两名患者，他们在先前的呼吸道感染后均因与LA相关的孤立性FX缺乏症而出现严重的出血素质。FX缺乏症和LA是短暂的。我们得出结论，患有LA的患者可能很少出现严重的获得性FX缺乏症。这可能是抗磷脂抗体患者出现出血并发症的另一种机制。
