Carruthers Jean, Carruthers Alastair, Maberley David
Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada.
Dermatol Surg. 2003 May;29(5):539-44. doi: 10.1046/j.1524-4725.2003.29127.x.
BTX-A is the standard treatment for glabellar furrows. However, some individuals have resting glabellar rhytides that are sufficiently deep that they respond poorly to BTX-A alone.
To compare the efficacy of BTX-A combined with intradermal Hylan B with the efficacy of BTX-A alone in individuals with moderate to severe glabellar rhytides.
This was a retrospective study of 16 subjects with moderate to severe glabellar rhytides. Their response to Hylan B plus BTX-A was compared clinically and photographically to their response to BTX-A alone.
All subjects had moderate or severe glabellar rhytides at rest before treatment. After BTX-A alone, none (0%) had achieved no or mild rhytides. After BTX-A and Hylan B injection, only 1 of 16 (6%) had moderate glabellar rhytides, with the remainder (94%) being mild.
Moderate to severe glabellar rhytides were treated better by BTX-A combined with Hylan B injection than by BTX-A alone.
肉毒杆菌毒素A（BTX-A）是治疗眉间纹的标准方法。然而，一些人静态眉间皱纹很深，单独使用BTX-A治疗效果不佳。
比较BTX-A联合真皮内注射透明质酸凝胶（Hylan B）与单独使用BTX-A治疗中度至重度眉间纹的疗效。
这是一项针对16例中度至重度眉间纹患者的回顾性研究。将他们对Hylan B加BTX-A的反应与单独使用BTX-A的反应进行临床和照片对比。
所有受试者治疗前静态时均有中度或重度眉间纹。单独使用BTX-A后，无人（0%）达到无皱纹或轻度皱纹状态。注射BTX-A和Hylan B后，16人中只有1人（6%）有中度眉间纹，其余（94%）为轻度。
对于中度至重度眉间纹，BTX-A联合Hylan B注射比单独使用BTX-A治疗效果更好。
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