肉毒毒素治疗面部皱纹：简要综述。
Botulinum toxins for facial lines: a concise review.
机构信息
The Cranley Clinic, 3 Harcourt House, 19a Cavendish Square, London, W1G 0PN UK ; UCLA School of Medicine, Los Angeles, CA USA.
出版信息
Dermatol Ther (Heidelb). 2012 Dec;2(1):14. doi: 10.1007/s13555-012-0014-6. Epub 2012 Sep 29.
Abstract
This is a concise review of the uses of botulinum toxins (BTXs) in dermatology and cosmetic procedures. It is a clinical rather than a basic science, pharmacological review. BTX had been initially used for selectively reducing and balancing periorbital muscle activity; thereby, reducing childhood strabismus and blepharospasm. This clinical research was initiated by Dr. Alan Scott over 40 years ago. BTX type A (BTX-A) was serendipitously observed to reduce forehead frown lines in patients being treated for blepharospasm. Extensive clinical research and development resulted in widespread aesthetic uses for BTX-A by reduction of selected hyperfunctional facial muscles. BTXs are also used for reduced localized hyperhidrosis. A topical BTX-A is being developed as a potential alternative to injected BTX.
摘要
这是一篇关于肉毒毒素（BTX）在皮肤科和美容程序中应用的简明综述。它是一篇临床综述，而非基础科学或药理学综述。BTX 最初被用于选择性地减少和平衡眼周肌肉的活动，从而减少儿童斜视和眼睑痉挛。这项临床研究由 Alan Scott 博士在 40 多年前发起。BTX-A 被意外地观察到可以减少正在接受眼睑痉挛治疗的患者的额部皱眉纹。广泛的临床研究和开发导致 BTX-A 被广泛用于减少选定的过度活跃的面部肌肉，从而实现美容效果。BTX 也用于减少局部多汗症。一种局部 BTX-A 正在被开发为注射 BTX 的潜在替代品。
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