Watson A D, McDonald P J
Am J Vet Res. 1976 May;37(5):557-9.
Chloramphenicol concentrations were assayed chemically in tissue homogenates, blood, and certain extravascular fluids of Greyhounds killed 1.5, 3, 6, and 12 hours after they were orally given the drug (50 mg/kg). The concentrations of hemoglobin in blood and tissue homogenates were used to estimate "corrected values" to allow for differences in vascularity of the tissues sampled. The distribution of chloramphenicol in the body was not uniform. In all sampled tissues except brain, the initial corrected values were higher than the concentrations in blood. The tissues sampled, in diminishing order of initial corrected value, were lymph node, spleen, pancreas, liver, kidney, lung, muscle, and brain. The persistence of antibiotic in different tissues varied, and in some tissues it was detectable when blood concentrations reached zero. Penetration of chloramphenicol into brain and cerebrospinal fluid was slower than in other tissues and fluids. In aqueous humor and cerebrospinal fluid, concentrations were lower than those in blood, but high concentrations were present in urine. The findings indicated that during chloramphenicol therapy it may be advantageous to select dosage frequencies according to the site of infection.
在给灵缇犬口服药物（50毫克/千克）后1.5、3、6和12小时处死，对其组织匀浆、血液和某些血管外液中的氯霉素浓度进行化学测定。利用血液和组织匀浆中的血红蛋白浓度来估算“校正值”，以考虑所取组织血管分布的差异。氯霉素在体内的分布并不均匀。除大脑外，所有取样组织的初始校正值均高于血液中的浓度。按初始校正值从高到低的顺序，所取组织依次为淋巴结、脾脏、胰腺、肝脏、肾脏、肺、肌肉和大脑。抗生素在不同组织中的存留情况各异，在某些组织中，当血液浓度降至零时仍可检测到。氯霉素进入大脑和脑脊液的速度比进入其他组织和液体的速度慢。在房水和脑脊液中，浓度低于血液中的浓度，但尿液中存在高浓度。研究结果表明，在氯霉素治疗期间，根据感染部位选择给药频率可能是有利的。
