Watson A D
Res Vet Sci. 1977 Jan;22(1):68-71.
On separate occasions, five fasted adult greyhounds were dosed orally with 50 mg chloramphenicol/kg, both alone and in conjunction with other drugs. The same five dogs were later given 50 mg chloramphenicol/kg when fed ad lib. Chloramphenicol levels in plasma were determined at intervals after dosing. The intial plasma chloramphenicol levels were higher when the drug was administered concurrently with calcium lactate tablets (50 mg/kg) or a proprietary enteric mixture containing kaolin, pectin, aluminium hydroxide and belladonna extract. Lower plasma levels resulted when the antibiotic was given with dry extract of belladonna (20 mg/dog) or intravenous chlorpromazine (2 mg/kg). There was no significant effect with coated ferrous gluconate tablets (30 mg/kg). Feeding ad lib increased the initial chloramphenicol levels, but produced lower levels subsequently.
在不同的时间点，分别给五只成年禁食灰狗口服50毫克氯霉素/千克，单独给药以及与其他药物联合给药。之后，同样这五只狗自由进食时再次给予50毫克氯霉素/千克。给药后定期测定血浆中的氯霉素水平。当该药物与乳酸钙片（50毫克/千克）或含有高岭土、果胶、氢氧化铝和颠茄提取物的专利肠溶混合物同时给药时，初始血浆氯霉素水平较高。当抗生素与颠茄干浸膏（20毫克/只狗）或静脉注射氯丙嗪（2毫克/千克）一起给药时，血浆水平较低。服用包衣葡萄糖酸亚铁片（30毫克/千克）没有显著影响。自由进食会提高初始氯霉素水平，但随后会产生较低的水平。
