易出错的聚合酶，即DNA聚合酶IV，负责大肠杆菌适应性突变过程中的瞬时高突变。
Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli.
作者信息
Tompkins Joshua D, Nelson Jennifer L, Hazel Jill C, Leugers Stacy L, Stumpf Jeffrey D, Foster Patricia L
机构信息
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA.
出版信息
J Bacteriol. 2003 Jun;185(11):3469-72. doi: 10.1128/JB.185.11.3469-3472.2003.
Abstract
The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutations that occur during hypermutation are due to Pol IV.
摘要
比较了有和没有易出错DNA聚合酶IV（Pol IV）的大肠杆菌菌株的适应性Lac（+）回复突变体中未选择突变的频率。在Pol IV缺陷型菌株中，该频率比野生型菌株低七倍多。因此，超突变过程中发生的突变是由Pol IV引起的。
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本文引用的文献
1
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Cold Spring Harb Symp Quant Biol. 2000;65:21-9. doi: 10.1101/sqb.2000.65.21.
2
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J Bacteriol. 2002 Oct;184(20):5599-608. doi: 10.1128/JB.184.20.5599-5608.2002.
3
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Genetics. 2002 Jul;161(3):945-56. doi: 10.1093/genetics/161.3.945.
4
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6
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