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The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).编码催化麦角硫因生物合成第一步的酶的糖基转移酶基因（mshA）。
J Bacteriol. 2003 Jun;185(11):3476-9. doi: 10.1128/JB.185.11.3476-3479.2003.
2
N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.N-乙酰基-1-D-肌醇-2-氨基-2-脱氧-α-D-吡喃葡萄糖苷脱乙酰酶（MshB）是分枝硫醇生物合成中的关键酶。
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3
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Arch Microbiol. 2002 Nov;178(5):331-7. doi: 10.1007/s00203-002-0462-y. Epub 2002 Aug 15.
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Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.耻垢分枝杆菌中麦角硫因生物合成途径的关键基因mshB的失活。
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本文引用的文献

1
Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics.巯基乙醇与结核分枝杆菌对有毒氧化剂和抗生素的保护作用之间的关联。
Mol Microbiol. 2003 Mar;47(6):1723-32. doi: 10.1046/j.1365-2958.2003.03416.x.
2
Mycothiol biochemistry.麦角硫因生物化学
Arch Microbiol. 2002 Dec;178(6):388-94. doi: 10.1007/s00203-002-0469-4. Epub 2002 Sep 3.
3
Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics.缺乏巯基乙醇的耻垢分枝杆菌突变体对烷化剂、自由基和抗生素高度敏感。
Antimicrob Agents Chemother. 2002 Nov;46(11):3348-55. doi: 10.1128/AAC.46.11.3348-3355.2002.
4
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes.放线菌中编码产生麦角硫因的乙酰转移酶的麦角硫因合酶基因（mshD）的鉴定。
Arch Microbiol. 2002 Nov;178(5):331-7. doi: 10.1007/s00203-002-0462-y. Epub 2002 Aug 15.
5
Sucrose metabolism: Anabaena sucrose-phosphate synthase and sucrose-phosphate phosphatase define minimal functional domains shuffled during evolution.蔗糖代谢：鱼腥藻蔗糖磷酸合酶和蔗糖磷酸磷酸酶定义了在进化过程中改组的最小功能域。
FEBS Lett. 2002 Apr 24;517(1-3):19-23. doi: 10.1016/s0014-5793(02)02516-4.
6
ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases.ATP 依赖性 L-半胱氨酸：1D-肌醇 2-氨基-2-脱氧-α-D-吡喃葡萄糖苷连接酶，即硫醇生物合成酶 MshC，与 I 类半胱氨酰-tRNA 合成酶相关。
Biochemistry. 2002 Jun 4;41(22):6885-90. doi: 10.1021/bi012212u.
7
Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.参与结核分枝杆菌磷脂酰肌醇三甘露糖苷生物合成的一种假定α-甘露糖基转移酶的特性分析
Biochem J. 2002 May 1;363(Pt 3):437-47. doi: 10.1042/0264-6021:3630437.
8
Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.剖析和操纵糖基磷脂酰肌醇锚生物合成途径。
Curr Opin Chem Biol. 2000 Dec;4(6):632-8. doi: 10.1016/s1367-5931(00)00151-4.
9
N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.N-乙酰基-1-D-肌醇-2-氨基-2-脱氧-α-D-吡喃葡萄糖苷脱乙酰酶（MshB）是分枝硫醇生物合成中的关键酶。
J Bacteriol. 2000 Dec;182(24):6958-63. doi: 10.1128/JB.182.24.6958-6963.2000.
10
Identification of essential amino acids in the bacterial alpha -mannosyltransferase aceA.细菌α-甘露糖基转移酶aceA中必需氨基酸的鉴定
J Biol Chem. 2000 Dec 22;275(51):40568-75. doi: 10.1074/jbc.M007496200.

编码催化麦角硫因生物合成第一步的酶的糖基转移酶基因（mshA）。

The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).

作者信息

Newton Gerald L, Koledin Teresa, Gorovitz Batia, Rawat Mamta, Fahey Robert C, Av-Gay Yossef

机构信息

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.

出版信息

J Bacteriol. 2003 Jun;185(11):3476-9. doi: 10.1128/JB.185.11.3476-3479.2003.

DOI:10.1128/JB.185.11.3476-3479.2003
PMID:12754249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC155378/
Abstract

Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA. The ortholog in Mycobacterium tuberculosis, Rv0486, was used to complement the mutant phenotype.

摘要

麦角硫因是大多数放线菌中存在的主要硫醇，由假二糖1D-肌醇2-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖苷（GlcNAc-Ins）产生。对耻垢分枝杆菌的一个转座子突变体进行测序，该突变体被证明缺乏GlcNAc-Ins和麦角硫因，以鉴定一个假定的糖基转移酶基因，命名为mshA。结核分枝杆菌中的直系同源基因Rv0486用于补充突变体表型。