Rahkonen T, Eloniemi-Sulkava U, Rissanen S, Vatanen A, Viramo P, Sulkava R
Division of Geriatrics, Department of Public Health and General Practice, University of Kuopio, Finland.
J Neurol Neurosurg Psychiatry. 2003 Jun;74(6):720-4. doi: 10.1136/jnnp.74.6.720.
To estimate the prevalence of dementia with Lewy bodies (DLB) according to the consensus criteria in a general population aged 75 years or older.
The "Kuopio 75+ study" is a population based health survey focused on the clinical epidemiology of dementia and functional capacity among elderly subjects aged 75 years or older. On 1 January 1998, a random sample of 700 subjects was drawn from a total population born before 1 January 1923, living in the city of Kuopio, northeast Finland (n = 4518). The study subjects underwent a structured interview and clinical examination.
601 elderly subjects (86% of the random sample) were examined. A dementia disorder was diagnosed in 137-a prevalence of 22.8% (95% confidence interval 19.4% to 26.2%). The prevalence of DLB was 5.0% (3.2% to 6.7%), comprising 22% of all demented subjects. Probable DLB was diagnosed in 20 subjects (3.3% (1.9% to 4.8%)), and possible DLB in 10 (1.7% (0.6% to 2.7%)). The prevalence of Alzheimer's disease was 10.6% (47% of all demented subjects), of vascular dementia, 5.3% (23%), and of other types of dementing disorders, 1.8% (8%).
In a general population aged 75 years and older, the prevalence of a disorder fulfilling the diagnostic criteria of DLB is half that of Alzheimer's disease and the same as for vascular dementia.
根据共识标准评估75岁及以上普通人群中路易体痴呆（DLB）的患病率。
“库奥皮奥75+研究”是一项基于人群的健康调查，重点关注75岁及以上老年受试者的痴呆临床流行病学和功能能力。1998年1月1日，从1923年1月1日前出生、居住在芬兰东北部库奥皮奥市的总人口（n = 4518）中随机抽取700名受试者作为样本。研究对象接受了结构化访谈和临床检查。
对601名老年受试者（随机样本的86%）进行了检查。诊断出137例痴呆症，患病率为22.8%（95%置信区间为19.4%至26.2%）。DLB的患病率为5.0%（3.2%至6.7%），占所有痴呆受试者的22%。确诊为可能的DLB的有20例（3.3%（1.9%至4.8%）），可能的DLB有10例（1.7%（0.6%至2.7%））。阿尔茨海默病的患病率为10.6%（占所有痴呆受试者的47%），血管性痴呆为5.3%（23%），其他类型的痴呆症为1.8%（8%）。
在75岁及以上的普通人群中，符合DLB诊断标准的疾病患病率是阿尔茨海默病的一半，与血管性痴呆相同。
