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糖尿病性多发性单神经炎：潜在免疫发病机制的证据。

Mononeuritis multiplex in diabetes mellitus: evidence for underlying immune pathogenesis.

作者信息

Kelkar P, Parry G J

机构信息

Department of Neurology, University of Iowa, Iowa City, Iowa, USA.

出版信息

J Neurol Neurosurg Psychiatry. 2003 Jun;74(6):803-6. doi: 10.1136/jnnp.74.6.803.

DOI:10.1136/jnnp.74.6.803
PMID:12754358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1738474/
Abstract

Four patients with type 2 diabetes mellitus developed mononeuritis multiplex subacutely. Sural nerve biopsies showed multifocal axonal loss in all patients, with epineurial perivascular inflammation affecting small calibre vessels in three. Three patients improved with immunotherapy. These observations suggest that mononeuritis multiplex in diabetes may be caused by an immune mediated vasculopathy and that it is pathogenetically akin to the more common and better recognised diabetic amyotrophy.

摘要

4例2型糖尿病患者亚急性发生多发性单神经炎。所有患者的腓肠神经活检均显示多灶性轴突丢失，3例患者存在神经外膜血管周围炎症，累及小口径血管。3例患者经免疫治疗后病情改善。这些观察结果提示，糖尿病性多发性单神经炎可能由免疫介导的血管病变引起，并且在发病机制上与更常见且更易识别的糖尿病性肌萎缩相似。

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Mononeuritis multiplex in diabetes mellitus: evidence for underlying immune pathogenesis.糖尿病性多发性单神经炎：潜在免疫发病机制的证据。
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Diabetic amyotrophy progressing to severe quadriparesis.糖尿病性肌萎缩进展为严重四肢瘫。
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