[Distribution and binding of oxytetracycline in the body of immunized animals].

Distribution and binding of oxytetracycline in immunized animals at various periods of immunogenesis (5, 10, 15, 20, 30 and 90 days after vaccination) were studied on rabbits, using dry live brucellosis vaccine, strain 19 as the antigen. The results of the study showed that immunological reconstruction of the macroorganism, its protective forces had a definite effect on the character of distribution, absorption and levels of oxytetracycline, as well as the processes of the antibiotic binding in the organism. The changes were indirect dependence on the immunogenesis periods: at the beginning of immunogenesis there was some increase in the antibiotic levels, as well as increased binding of the drug in the organs where reconstruction, activation and hyperplasia of the lymphoreticular cells occurred. During the productive phase of the antigen formation the antibiotic levels were 1,5-2 times lower, however, the processes of the antibiotic binding were more pronounced in the organs, where immunocompetent cells and antibodies were synthesized. During extinction of immunogenesis reduction of the initial antibiotic levels was recorded. Therefore, the changes directly depended on the periods of immunogenesis.