Ambartsumian L A, Danielova L T
Antibiotiki. 1977 Jan;22(1):56-60.
Some regularities of distribution and binding of streptomycin in the blood, organs and tissues of immunized rabbits werer studied. The leveles of the bound and free antibiotic in ther were determined. It was found that the immunobiological state of the rabbits had a definite effect on the distribution character and binding of streptomycin with proteins and cells in the animal organs and tissues. These changes were most pronounced in the organs and tissues of lymphoid and hematopoietic systems, the cells of which are indirect active participants of the immunity formation. As a result of proliferation of these cells the antibiotic was accumulated in higher amounts and bound more actively especially in the thymus gland and bone marrow, the central organs of the immunological reconstruction of the host. The studies are indicative of the presence of interaction between immunogenesis, distribution and binding of streptomycin in immunized animals.
研究了链霉素在免疫兔的血液、器官和组织中的分布及结合规律。测定了其中结合型和游离型抗生素的水平。发现兔的免疫生物学状态对链霉素在动物器官和组织中与蛋白质及细胞的分布特征和结合有一定影响。这些变化在淋巴和造血系统的器官和组织中最为明显，其细胞是免疫形成的间接活跃参与者。由于这些细胞的增殖，抗生素在这些器官中大量蓄积且结合更为活跃，尤其是在胸腺和骨髓中，这两个器官是宿主免疫重建的中枢器官。这些研究表明免疫发生、链霉素在免疫动物体内的分布及结合之间存在相互作用。
