Danielova L T, Ambartsumian L A
Antibiotiki. 1975 Jan;20(1):18-22.
Distribution of unbound and bound monomycin in rabbits immunized against paratyphoid fever and colibacteriosis was studied at various stages of the immunization. The studies showed that the immunological reconstruction had a definite effect on the distribution character and the processes of the antibiotic binding in the vaccinized rabbits. The binding processes in the lymphoid cells increased, while those in the parenchimatose cells decreased. The concentration of the unbound and bound preparation in the organs and tissues at the background of the immunity was 2-3 times lower than that in the non-immunized animals. The bone marrow, where it markedly increased was an exception.
研究了在免疫不同阶段，副伤寒热和大肠杆菌病免疫兔体内未结合和结合态间霉素的分布情况。研究表明，免疫重建对疫苗接种兔体内抗生素的分布特征和结合过程有明确影响。淋巴细胞中的结合过程增加，而实质细胞中的结合过程减少。免疫背景下器官和组织中未结合和结合制剂的浓度比未免疫动物低2 - 3倍。骨髓是个例外，其浓度显著增加。
