Azad Rajvardhan, Ravi Keshavamurthy, Talwar Dinesh, Kumar Neena
Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Graefes Arch Clin Exp Ophthalmol. 2003 Jun;241(6):478-83. doi: 10.1007/s00417-003-0670-4. Epub 2003 May 14.
Results of core vitrectomy in post-traumatic endophthalmitis are poor. Our initial results of complete vitrectomy with primary silicone oil endotamponade were promising. A comparative study of this procedure with conventional core vitrectomy was therefore carried out.
A prospective randomized controlled study of 24 consecutive cases of post-traumatic endophthalmitis was conducted. Patients were randomized into two groups in the absence of clinical improvement after primary tap and treatment with intravitreal vancomycin and amikacin: group 1 consisted of patients who underwent core vitrectomy alone, group 2 of patients who underwent complete vitrectomy with silicone oil endotamponade. All patients included in the study received intravenous antibiotics and underwent lensectomy. Patients were followed up 1, 2, 4 and 12 weeks postoperatively. In all patients of group 2, silicone oil was removed 6 weeks after primary surgery. The mean duration of follow-up was 112+/-55 days.
Vision of 20/400 or better was obtained in 58.33% of cases (14/24). Visual acuity of only one patient in group 1 was >or=20/200, compared with that of 58.3% of patients (7/12) in group 2 ( P=0.02). Intra-operative retinal breaks were found in 50% (6/12) of the patients belonging to group 1, but did not affect the final visual outcome. In group 1, 33.33% (4/12) developed rhegmatogenous retinal detachment in the immediate post-operative period. Only one of these patients had useful final visual outcome after resurgery.
Complete vitrectomy with primary silicone oil endotamponade is a useful treatment modality which improves the anatomical and functional results in post-traumatic endophthalmitis.
创伤性眼内炎行核心玻璃体切除术的效果不佳。我们采用初次硅油眼内填充行完全玻璃体切除术的初步结果令人鼓舞。因此,对该手术与传统核心玻璃体切除术进行了一项对比研究。
对24例连续性创伤性眼内炎患者进行了一项前瞻性随机对照研究。在初次穿刺及玻璃体内注射万古霉素和阿米卡星治疗后若临床症状无改善,将患者随机分为两组:第1组患者仅接受核心玻璃体切除术,第2组患者接受完全玻璃体切除术并硅油眼内填充。纳入研究的所有患者均接受静脉抗生素治疗并进行晶状体切除术。术后1周、2周、4周和12周对患者进行随访。第2组所有患者在初次手术后6周取出硅油。平均随访时间为112±55天。
58.33%(14/24)的病例视力达到20/400或更好。第1组仅1例患者视力≥20/200,而第2组为58.3%(7/12)的患者(P = 0.02)。第1组50%(6/12)的患者术中发现视网膜裂孔,但未影响最终视力结果。在第1组中,33.33%(4/12)的患者在术后短期内发生孔源性视网膜脱离。这些患者中只有1例再次手术后获得了有用的最终视力结果。
初次硅油眼内填充行完全玻璃体切除术是一种有效的治疗方式,可改善创伤性眼内炎的解剖和功能结果。