Gupta Aditya K, Ryder Jennifer E, Baran Robert, Summerbell Richard C
Division of Dermatology, Department of Medicine, Sunnybrook and Women's College Health Science Center (Sunnybrook site), Toronto, Canada.
Dermatol Clin. 2003 Apr;21(2):257-68. doi: 10.1016/s0733-8635(02)00086-4.
Non-dermatophyte organisms are becoming increasingly prevalent in onychomycosis. This apparent emergence might be an artifact of improved diagnostic techniques and increased awareness that these fungi are potential etiologic agents. It is important to bear in mind that all isolated organisms should be evaluated as potential pathogens when diagnosing fungal infections, especially given the increasing use of immunosuppressive drugs and the increasing numbers of chronically immunocompromised individuals. While many patients with non-dermatophyte mold onychomycosis will respond to oral or topical antifungal therapy, poor or incomplete response might still be expected in some patients.
非皮肤癣菌性微生物在甲癣中越来越普遍。这种明显的增多可能是诊断技术改进以及对这些真菌作为潜在病原体的认识提高所导致的假象。在诊断真菌感染时，必须牢记所有分离出的微生物都应作为潜在病原体进行评估，特别是考虑到免疫抑制药物的使用日益增加以及慢性免疫功能低下个体数量不断增多的情况。虽然许多非皮肤癣菌性霉菌引起的甲癣患者对口服或外用抗真菌治疗有反应，但仍可能有一些患者反应不佳或不完全。
