Blasco María A
Department of Immunology and Oncology, National Centre of Biotechnology, E-28049, Madrid, Spain.
Cancer Lett. 2003 May 15;194(2):183-8. doi: 10.1016/s0304-3835(02)00705-x.
The analysis of mice deficient in telomerase activity has allowed to directly test the relevance of telomeres and telomerase in tumor development and aging in the context of a mammalian organism. More recently, mice with impaired telomere capping due to abrogation of telomere-binding proteins have been also characterized. Here, I will discuss these studies, as well as their implications for putative therapies based of telomerase inhibition of telomerase re-introduction for cancer or age-related diseases, respectively.
对端粒酶活性缺乏的小鼠进行分析，使得在哺乳动物机体的背景下，能够直接测试端粒和端粒酶在肿瘤发生及衰老过程中的相关性。最近，因端粒结合蛋白缺失而导致端粒封端受损的小鼠也得到了表征。在此，我将讨论这些研究，以及它们分别对基于抑制端粒酶或重新引入端粒酶来治疗癌症或与年龄相关疾病的潜在疗法的意义。
