木霉菌素对网织红细胞裂解物中蛋白质合成的抑制作用。
Inhibition of protein synthesis in reticulocyte lysates by trichodermin.
作者信息
Carter C J, Cannon M, Smith K E
出版信息
Biochem J. 1976 Jan 15;154(1):171-8. doi: 10.1042/bj1540171.
Abstract
- The effect of trichodermin as an inhibitor of eukaryotic protein synthesis was studied in a reticulocyte cell-free system. 2. Trichodermin at a concentration of 25 mug/ml inhibits total protein synthesis instantaneously and stabilizes polyribosome profiles. Conversely, at a concentration of 0.25 mug/ml the drug inhibits total protein synthesis by only 70-75% and allows 30-35% breakdown of the polyribosomes in the system. These effects were compared with those produced by two other drugs (pactamycin and anisomycin) examined under conditions identical with those used for trichodermin.
摘要
- 在网织红细胞无细胞体系中研究了抗霉素作为真核生物蛋白质合成抑制剂的作用。2. 浓度为25微克/毫升的抗霉素能瞬间抑制总蛋白质合成并稳定多核糖体图谱。相反，浓度为0.25微克/毫升时，该药物仅抑制70 - 75%的总蛋白质合成，并使体系中的多核糖体有30 - 35%发生解体。将这些效应与在与抗霉素相同的条件下检测的另外两种药物（ pactamycin和茴香霉素）所产生的效应进行了比较。
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本文引用的文献
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