Chu Kon, Kim Manho, Jeong Sang-Wuk, Kim Seung U, Yoon Byung-Woo
Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
Neurosci Lett. 2003 Jun 5;343(2):129-33. doi: 10.1016/s0304-3940(03)00174-5.
Intraparenchymally transplanted rodent-origin neural and human-origin mesenchymal stem cells migrate and differentiate in neurological diseases. By intravenously injecting human neural stem cells, we showed that transplanted human neural stem cells migrate to the damaged hippocampus, proliferate and differentiate into mature neurons and astrocytes in the adult rat brain with transient forebrain ischemia. We also demonstrated the migratory course of implanted human neural stem cells after intravenous injection. Our findings show that transplanted human neural stem cells differentiate into mature neurons to replace lost neural cells in the adult hippocampus with human-rat neural chimeras.
脑实质内移植的啮齿动物源神经干细胞和人源间充质干细胞在神经疾病中会发生迁移和分化。通过静脉注射人神经干细胞，我们发现，在成年大鼠短暂性前脑缺血模型中，移植的人神经干细胞会迁移至受损海马区，增殖并分化为成熟神经元和星形胶质细胞。我们还展示了静脉注射后人神经干细胞的迁移过程。我们的研究结果表明，移植的人神经干细胞可分化为成熟神经元，以人-大鼠神经嵌合体的形式替代成年海马体中丢失的神经细胞。
