Wang Yu, Cao Yirong, Xie Wanqing, Guo Yunlu, Cai Jiayi, Huang Tingting, Li Peiying
Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Cereb Blood Flow Metab. 2025 Apr;45(4):600-616. doi: 10.1177/0271678X251317374. Epub 2025 Jan 30.
Stem cell-based therapies have raised considerable interest to develop regenerative treatment for neurological disorders with high disability. In this review, we focus on recent preclinical and clinical evidence of stem cell therapy in the treatment of degenerative neurological diseases and discuss different cell types, delivery routes and biodistribution of stem cell therapy. In addition, recent advances of mechanistic insights of stem cell therapy, including functional replacement by exogenous cells, immunomodulation and paracrine effects of stem cell therapies are also demonstrated. Finally, we also highlight the adjunction approaches that has been implemented to augment their reparative function, survival and migration to target specific tissue, including stem cell preconditioning, genetical engineering, co-transplantation and combined therapy.
基于干细胞的疗法引发了人们极大的兴趣，以开发针对高度致残性神经系统疾病的再生治疗方法。在这篇综述中，我们重点关注干细胞疗法在治疗退行性神经疾病方面的最新临床前和临床证据，并讨论干细胞疗法的不同细胞类型、递送途径和生物分布。此外，还展示了干细胞疗法机制研究的最新进展，包括外源性细胞的功能替代、免疫调节和干细胞疗法的旁分泌作用。最后，我们还强调了为增强其修复功能、存活能力以及向特定靶组织迁移而实施的辅助方法，包括干细胞预处理、基因工程、联合移植和联合治疗。
