5-脂氧合酶（5-LOX）与环氧化酶（COX）双重抑制剂、选择性及非选择性非甾体抗炎药的治疗作用
Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.
作者信息
Martel-Pelletier J, Lajeunesse D, Reboul P, Pelletier J-P
机构信息
Osteoarthritis Research Unit, Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Québec H2L 4M1 Canada.
出版信息
Ann Rheum Dis. 2003 Jun;62(6):501-9. doi: 10.1136/ard.62.6.501.
Abstract
Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.
摘要
双重5-脂氧合酶/环氧化酶抑制剂是治疗炎症的潜在新药。它们通过阻断前列腺素和白三烯的形成发挥作用，但不影响脂氧素的形成。这种联合抑制避免了选择性环氧化酶-2抑制剂的一些缺点，并保护了胃肠道黏膜。
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