连续或间歇输注后万古霉素在未感染胸腔积液渗出液中的渗透情况。
Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion.
作者信息
Byl Baudouin, Jacobs Frédérique, Wallemacq Pierre, Rossi Camelia, de Francquen Philippe, Cappello Matteo, Leal Teresinha, Thys Jean-Pierre
机构信息
Infectious Diseases Clinic, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
出版信息
Antimicrob Agents Chemother. 2003 Jun;47(6):2015-7. doi: 10.1128/AAC.47.6.2015-2017.2003.
Abstract
Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).
摘要
从16例肺手术后接受间歇或持续输注万古霉素的患者中采集血液和胸腔渗出液样本。两种给药方案下血液和胸腔渗出液的浓度-时间曲线下面积相同，而持续输注使胸腔渗出液中的浓度更持久（平均浓度为12毫克/升）。
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