Jones J B, Yang T J, Dale J B, Lange R D
Br J Haematol. 1975 Jun;30(2):215-23. doi: 10.1111/j.1365-2141.1975.tb00535.x.
Dogs affected with cyclic haematopoiesis (CH) and experiencing recurrent 12-day cycles of neutropenia were supralethally irradiated and transplanted with marrow from their normal littermates. Following transplantation of the normal marrow, dogs with CH experienced no further cycles of neutropenia. Platelet and reticulocyte numbers also ceased to fluctuate cyclically in these dogs. The marrows of dogs with CH were transplanted into unaffected supralethally irradiated littermates. Prompt engraftment occurred in the recipient dogs with subsequent cyclic rises and falls of the numbers of platelets, reticulocytes and neutrophils. In the post-transplant period, immunosuppressant drugs were not used in three of the recipients and the fourth received only a single 5 mg dose of methotrexate.
患有周期性造血（CH）且经历12天周期性中性粒细胞减少的犬只接受了超致死剂量的辐射，并移植了来自其正常同窝仔犬的骨髓。移植正常骨髓后，患有CH的犬只不再经历中性粒细胞减少的周期。这些犬只的血小板和网织红细胞数量也不再周期性波动。患有CH的犬只的骨髓被移植到未受影响且接受了超致死剂量辐射的同窝仔犬体内。受体犬迅速发生植入，随后血小板、网织红细胞和中性粒细胞数量出现周期性升降。在移植后的时期，三只受体未使用免疫抑制药物，第四只仅接受了单次5毫克剂量的甲氨蝶呤。
