犬周期性中性粒细胞减少症。一种干细胞缺陷。
Canine cyclic neutropenia. A stem cell defect.
作者信息
Weiden P L, Robinett B, Graham T C, Adamson J, Storb R
出版信息
J Clin Invest. 1974 Mar;53(3):950-3. doi: 10.1172/JCI107636.
Abstract
Two normal collie dogs were given 1,200 R total body irradiation followed by successful marrow grafts from their grey collie littermates with cyclic hematopoiesis. During observation periods of 97 and 41 days after grafting, both previously normal recipients showed regular cyclic fluctuations of their granulocyte and reticulocyte counts similar to those observed in their donors. These findings suggest that canine cyclic neutropenia is due to a defect in the marrow stem cell.
摘要
给两只正常的柯利犬进行了全身1200伦琴的照射，随后成功地从患有周期性造血的灰色柯利同窝幼仔身上移植了骨髓。在移植后97天和41天的观察期内，两只先前正常的受体的粒细胞和网织红细胞计数均呈现出规则的周期性波动，类似于在其供体中观察到的情况。这些发现表明，犬类周期性中性粒细胞减少症是由于骨髓干细胞缺陷所致。
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本文引用的文献
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