Hammond W P, Price T H, Dale D C
Blood. 1978 Dec;52(6):1170-7.
Endotoxin was given to grey collie dogs to investigate the mechanism of cyclic hematopoiesis. Over prolonged periods of daily administration, low doses of endotoxin (0.1 microgram/kg/day) failed to change the cycling of blood neutrophils or reticulocytes. However, higher doses of endotoxin maintained at a plateau level (5 microgram/kg/day) eliminated the cyclic changes in neutrophils and stabilized the reticulocyte and platelet counts in the normal range. Administration of endotoxin at this dose also eliminated the cyclic marrow differential count fluctuations characteristic of this disease. We infer from these results that endotoxin ameliorates the cyclical changes in blood cell counts by regulating hematopoietic proliferative activity at the stem cell level.
给灰色柯利犬注射内毒素以研究循环性造血的机制。在长期每日给药过程中，低剂量内毒素（0.1微克/千克/天）未能改变血液中性粒细胞或网织红细胞的循环。然而，维持在平台水平的较高剂量内毒素（5微克/千克/天）消除了中性粒细胞的周期性变化，并使网织红细胞和血小板计数稳定在正常范围内。以该剂量给予内毒素也消除了该疾病特有的骨髓细胞分类计数的周期性波动。我们从这些结果推断，内毒素通过在干细胞水平调节造血增殖活性来改善血细胞计数的周期性变化。
