Rome R M, Simmons S C, Bearne M, Watson D
Br J Obstet Gynaecol. 1976 Jun;83(6):441-6. doi: 10.1111/j.1471-0528.1976.tb00862.x.
The lecithin-sphingomyelin (LS) ratio is a good, but not absolute, test of fetal lung maturity. A total of 373 infants was delivered within 72 hours of amniotic fluid collection for assessment of the L/S ratio. Five of 43 infants (11-6 per cent) with an L/S ratio of 2-2 or less developed the respiratory distress syndrome (RDS), whereas only one of 320 infants (0-31 per cent) with a higher L/S ratio developed RDS. The risk of RDS could be further defined by using the creatinine concentration (critical value 19 mg/1) and the Nile blue sulphate test (critical value 4 per cent) in combination with the L/S ratio. All three tests were performed in 320 pregnancies and in each instance delivery took place within 72 hours. When all three test results were low, 3 of 5 infants (60 per cent) developed RDS, whereas when all three results were high, none of 175 infants developed RDS. When one or two results were low, 2 of 140 infants (1-4 per cent) developed RDS.
卵磷脂 - 鞘磷脂（L/S）比值是检测胎儿肺成熟度的一项有效但并非绝对的指标。在采集羊水以评估L/S比值后的72小时内，共分娩了373名婴儿。L/S比值为2.2或更低的43名婴儿中有5名（11.6%）发生了呼吸窘迫综合征（RDS），而L/S比值较高的320名婴儿中只有1名（0.31%）发生了RDS。结合肌酐浓度（临界值19mg/1）和尼罗蓝硫酸盐试验（临界值4%）与L/S比值，可以进一步明确发生RDS的风险。在320例妊娠中进行了所有这三项检测，且每次分娩均在72小时内进行。当所有三项检测结果均为低值时，5名婴儿中有3名（60%）发生了RDS，而当所有三项结果均为高值时，175名婴儿中无一例发生RDS。当一两项结果为低值时，140名婴儿中有2名（1.4%）发生了RDS。
