Campbell Kenneth
Division of Developmental Biology, Children's Hospital Research Foundation, Cincinnati, Ohio.
Glia. 2003 Jul;43(1):44-46. doi: 10.1002/glia.10247.
Radial glia represent the major glial cell type in the developing CNS and perform many essential functions, which range from acting as neural precursors to providing physical substrates for newborn neurons to migrate on. Previous work has shown that cell-cell signaling is important for the development of the radial glial phenotype. In particular, signals from newborn neurons appear to contribute significantly to the formation of this cell type. In addition, radial glia may be involved in reciprocal signaling roles that contribute to regional patterning and differentiation in the developing CNS.
放射状胶质细胞是发育中的中枢神经系统中的主要胶质细胞类型，执行许多重要功能，范围从充当神经前体细胞到为新生神经元提供迁移的物理基质。先前的研究表明，细胞间信号传导对放射状胶质细胞表型的发育很重要。特别是，来自新生神经元的信号似乎对这种细胞类型的形成有显著贡献。此外，放射状胶质细胞可能参与相互信号传导作用，这有助于发育中的中枢神经系统的区域模式形成和分化。
