Severin S E, Bushuev V N, Shnol' S E, Vishnevskaia Z I, Golovanov I B
Biokhimiia. 1976 Jan;41(1):197-201.
It is shown that the formation of a carnosine--nucleotide complex (ATP, ADP, AMP) takes place. The stability of the complex mainly depends on: 1) the staking interaction between the heterocyclic rings of carnosine and nucleotides; 2) the electrostatic interaction between the phosphate groups of nucleotide and the positive charged amino group NH3+ of the beta-alanine part of carnosine. The formation of the hydrogen bond between dipeptide COO- group and N1 or N7 of nucleotide is also possible. The complex stability strongly depends on the charge-state of the components and little on the number of the phosphate groups of nucleotide (ATP greater than or equal to ADP greater than AMP).
结果表明，肌肽与核苷酸（ATP、ADP、AMP）形成了复合物。该复合物的稳定性主要取决于：1）肌肽和核苷酸杂环之间的堆积相互作用；2）核苷酸磷酸基团与肌肽β-丙氨酸部分带正电荷的氨基NH3+之间的静电相互作用。二肽COO-基团与核苷酸的N1或N7之间也可能形成氢键。复合物的稳定性强烈依赖于各组分的电荷状态，而对核苷酸磷酸基团的数量依赖性较小（ATP≥ADP＞AMP）。
