螺旋星衫鱼素A的两个非对映异构体C1-C22片段的合成。

Synthesis of two diastereomeric C1-C22 fragments of spirastrellolide A.

作者信息

Paterson Ian, Anderson Edward A, Dalby Stephen M, Genovino Julien, Lim Jong Ho, Moessner Christian

机构信息

University Chemical Laboratory, Lensfield Road, Cambridge, UK.

出版信息

Chem Commun (Camb). 2007 May 14(18):1852-4. doi: 10.1039/b700827a. Epub 2007 Feb 14.

DOI:10.1039/b700827a

PMID:17476409

Abstract

The optimisation of a synthetic strategy towards the ABC segment of the cytotoxic macrolide spirastrellolide A is reported, together with its application to the synthesis of two diastereomeric C(1)-C(22) fragments for stereochemical correlation purposes with a putative spirastrellolide degradation product.

摘要

报道了一种针对细胞毒性大环内酯类螺旋星孢菌素A的ABC片段的合成策略的优化，以及该策略在合成两个非对映异构的C(1)-C(22)片段中的应用，用于与一种假定的螺旋星孢菌素降解产物进行立体化学关联。