Gleye Christophe, Lewin Guy, Laurens Alain, Jullian Jean-Christophe, Loiseau Philippe, Bories Christian, Hocquemiller Reynald
Laboratoire de Pharmacognosie, UMR 8076 CNRS (BioCIS), Faculté de Pharmacie, Université Paris XI, 92296 Châtenay-Malabry Cedex, France.
J Nat Prod. 2003 May;66(5):690-2. doi: 10.1021/np020563j.
The acaricidal effects of tonka bean, Dipterix odorata, extracts were investigated on Dermatophagoides pteronyssinus, the European house dust mite, and compared with benzyl benzoate as a standard acaricidal compound. A cyclohexane extract was the most effective, with an EC(50) = 0.075 g/m(2) after a 24 h period, as compared with benzyl benzoate (0.025 g/m(2)). Bioassay-guided fractionation of this extract led to the isolation of coumarin (1). Pharmacomodulation of this compound led us to test 20 analogues (2-21), which were either synthesized or purchased.
研究了零陵香豆（Dipterix odorata）提取物对欧洲家尘螨嗜肺螨（Dermatophagoides pteronyssinus）的杀螨效果，并与作为标准杀螨化合物的苯甲酸苄酯进行了比较。环己烷提取物最有效，24小时后的半数有效浓度（EC50）为0.075 g/m²，而苯甲酸苄酯为0.025 g/m²。对该提取物进行生物测定导向的分级分离，得到了香豆素（1）。对该化合物进行药效调节，促使我们测试了20种类似物（2-21），这些类似物要么是合成的，要么是购买的。
