Winer Nathaniel, Sowers James R
Division of Endocrinology, Diabetes, and Hypertension, Box 1205, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USA.
Curr Diab Rep. 2003 Jun;3(3):230-4. doi: 10.1007/s11892-003-0069-y.
The measurement of vascular compliance has assumed increasing importance as a powerful predictor of cardiovascular and all-cause mortality. Arterial stiffness increases with the duration of diabetes, older age, and concomitant hypertension. Hyperglycemia may increase arterial stiffness in diabetes by reducing the bioactivity of endothelium-derived nitric oxide (NO) either by decreasing NO production or inactivating NO by interaction with oxygen-derived free radicals. New approaches to therapy, such as the use of advanced glycation end product "breakers," may potentially benefit patients with diabetes.
血管顺应性的测量作为心血管疾病和全因死亡率的有力预测指标，其重要性日益凸显。动脉僵硬度会随着糖尿病病程、年龄增长以及合并高血压而增加。高血糖可能通过减少内皮源性一氧化氮（NO）的生成或使其与氧自由基相互作用而失活，从而降低NO的生物活性，进而增加糖尿病患者的动脉僵硬度。新的治疗方法，如使用晚期糖基化终末产物“破坏剂”，可能会使糖尿病患者受益。
