Barkova E N, Petrov A V
Biull Eksp Biol Med. 1976 Feb;81(2):156-8.
Under the effect of high-pressure oxygen therapy (2 atm of O2 for 40 min) in anemic rats (blood loss - 2,8% of body weight in the course of 30 min) erythropoiesis in the bone marrow was more intense and led to effective restoration of erythrocytes and hemoglobin in the peripheral blood. Biphasic character of accumulation of erythropoientins in the blood serum of rats was seen on the 1st and the 10th days after acute blood loss. Erythropoiesis inhibitor was revealed in the blood serum of rats on the 15th day. A conclusion was drawn on the importance of erythropoietins and high pressure oxygen therapy in the mechanism of blood regeneration following the loss of blood.
在失血性贫血大鼠（30分钟内失血占体重的2.8%）接受高压氧治疗（2个大气压的氧气，持续40分钟）后，骨髓中的红细胞生成更为活跃，导致外周血中的红细胞和血红蛋白有效恢复。急性失血后第1天和第10天，大鼠血清中促红细胞生成素的积累呈现双相性。在第15天，大鼠血清中发现了红细胞生成抑制剂。得出结论，促红细胞生成素和高压氧治疗在失血后血液再生机制中具有重要作用。
