Proekt Alex, Weiss Klaudiusz R
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
J Neurosci. 2003 May 15;23(10):4029-33. doi: 10.1523/JNEUROSCI.23-10-04029.2003.
Improvement of behavioral responses to expected stimuli has been attributed to a change in the preparatory state. In this study, we take advantage of the accessibility of the nervous system of Aplysia and develop an in vitro analog of the preparatory state for feeding behaviors. We provide evidence that the change in the preparatory state may be elicited initially by activity of identified serotonergic metacerebral cells (MCCs). We demonstrate, however, that the preparatory state is maintained through MCC-independent repetition priming that is embedded in the properties of the behavior-generating network. Both MCC-dependent and MCC-independent processes converge on the same site in the behavior-generating network to mediate the change in the preparatory state. Thus, we propose a model of how multiple neuronal structures interact to elicit and maintain changes in the preparatory states in the CNS.
对预期刺激的行为反应改善归因于准备状态的变化。在本研究中，我们利用海兔神经系统的可及性，开发了一种用于进食行为的准备状态的体外类似物。我们提供的证据表明，准备状态的变化最初可能由已识别的5-羟色胺能大脑后叶细胞（MCCs）的活动引发。然而，我们证明，准备状态是通过嵌入行为产生网络特性中的不依赖MCC的重复启动来维持的。依赖MCC和不依赖MCC的过程都汇聚在行为产生网络中的同一部位，以介导准备状态的变化。因此，我们提出了一个关于多种神经元结构如何相互作用以引发和维持中枢神经系统中准备状态变化的模型。
