Durikhin K V
Biull Eksp Biol Med. 1976;81(4):452-4.
Experiments were conducted on a model of edema of albino mouse paws; a study was made of the effect of neuraminidase inhibitors on the cholerogenic effect of a filtrate of cholera vibrio culture. It appeared that addition to the filtrate of inhibitors depressed its biological activity. Since no cholerogenic action was possessed by the purified neuraminidase preparations from the cholera vibrios it was suggested that there existed a chemical affinity between the region of cholerogen responsible for fixation on the cell membranes and the active neuraminidase centre.
对白化病小鼠爪部水肿模型进行了实验；研究了神经氨酸酶抑制剂对霍乱弧菌培养滤液致霍乱作用的影响。结果表明，在滤液中添加抑制剂会降低其生物活性。由于从霍乱弧菌中纯化得到的神经氨酸酶制剂不具有致霍乱作用，因此有人提出，负责固定在细胞膜上的霍乱原区域与活性神经氨酸酶中心之间存在化学亲和力。
