[霍乱弧菌神经氨酸酶对劳舍尔小鼠白血病的抑制作用]
[Inhibiting effect of cholera vibrio neuraminidase in Rauscher mouse leukemia].
作者信息
Barinskiĭ I F, Korbinskiĭ G D
出版信息
Biull Eksp Biol Med. 1976;82(11):1357-9.
PMID:1016719
Abstract
A study was made of the inhibitory effect of neuraminidase of cholera vibrio in mouse Rauscher leukemia. It was shown that the processing of cells of the spleen of mice suffering from leukemia with neuraminidase (in a dose of 50 units/ml and more) significantly inhibited the capacity of these cells to induce leukemia in their injection to BALB/c mice. In the mentioned concentration neuraminidase injected repeatedly parenterally produced no therapeutic effect in Rauscher leukemia.
摘要
对霍乱弧菌神经氨酸酶对小鼠劳舍尔白血病的抑制作用进行了研究。结果表明，用神经氨酸酶（剂量为50单位/毫升及以上）处理患白血病小鼠的脾脏细胞，显著抑制了这些细胞在注射给BALB/c小鼠时诱发白血病的能力。在上述浓度下，经胃肠外反复注射神经氨酸酶对劳舍尔白血病没有治疗效果。
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