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阿司匹林对人血小板摄取和释放5-羟色胺的影响。

The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets.

作者信息

Rendu F

出版信息

Br J Pharmacol. 1976 May;57(1):149-51. doi: 10.1111/j.1476-5381.1976.tb07665.x.

DOI:10.1111/j.1476-5381.1976.tb07665.x
PMID:1276534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1667011/
Abstract

The influence of aspirin on 5-hydroxytryptamine (5-HT) uptake and storage by human blood platelets has been investigated. Uptake of 5-HT was strongly inhibited. In 30 min aspirin released 50% of the 5-HT that had been incorporated into the platelets prior to the addition of the aspirin. These results are discussed in terms of possible interference with a 5-HT membrane receptor and the impairment of 5-HT storage in the dense granules.

摘要

研究了阿司匹林对人血小板摄取和储存5-羟色胺（5-HT）的影响。5-HT的摄取受到强烈抑制。在30分钟内，阿司匹林释放出了在添加阿司匹林之前已被血小板摄取的5-HT的50%。从可能对5-HT膜受体的干扰以及致密颗粒中5-HT储存受损的角度对这些结果进行了讨论。

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1
The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets.阿司匹林对人血小板摄取和释放5-羟色胺的影响。
Br J Pharmacol. 1976 May;57(1):149-51. doi: 10.1111/j.1476-5381.1976.tb07665.x.
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引用本文的文献

1
Aspirin at therapeutic concentrations does not affect 5-hydroxytryptamine uptake by platelets.治疗浓度的阿司匹林不影响血小板对5-羟色胺的摄取。
Br J Pharmacol. 1977 Apr;59(4):661-2. doi: 10.1111/j.1476-5381.1977.tb07735.x.

本文引用的文献

1
The effect of salicylates on the hemostatic properties of platelets in man.水杨酸盐对人体血小板止血特性的影响。
J Clin Invest. 1968 Sep;47(9):2169-80. doi: 10.1172/JCI105903.
2
Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion.摄入乙酰水杨酸对二磷酸腺苷诱导的继发性聚集及其他血小板功能的抑制作用。
Proc Soc Exp Biol Med. 1968 Feb;127(2):547-51. doi: 10.3181/00379727-127-32737.
3
Uptake, metabolism, storage, and release of 5-hydroxytryptamine in blood platelets.5-羟色胺在血小板中的摄取、代谢、储存及释放
Res Clin Stud Headache. 1970;3:202-13.
4
Mechanism of prostaglandin biosynthesis. 3. Catecholamines and serotonin as coenzymes.前列腺素生物合成机制。3. 儿茶酚胺和5-羟色胺作为辅酶。
J Am Chem Soc. 1970 Nov 4;92(22):6670. doi: 10.1021/ja00725a064.
5
On the mechanism of platelet function inhibition by acetylsalicylic acid.关于乙酰水杨酸抑制血小板功能的机制
Proc Soc Exp Biol Med. 1970 Feb;133(2):632-6. doi: 10.3181/00379727-133-34533.
6
Cell membrane damage, platelet stickiness and some effects of aspirin.
Br J Haematol. 1969 Dec;17(6):610-1.
7
Aspirin selectively inhibits prostaglandin production in human platelets.阿司匹林可选择性抑制人体血小板中前列腺素的生成。
Nat New Biol. 1971 Jun 23;231(25):235-7. doi: 10.1038/newbio231235a0.
8
Serotonin receptors, VII. Activities of various pure gangliosides as the receptors.血清素受体，VII。各种纯神经节苷脂作为受体的活性。
Proc Natl Acad Sci U S A. 1965 May;53(5):959-63. doi: 10.1073/pnas.53.5.959.
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Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.5-羟色胺及几种类似物对人体血小板的相对活性及摄取情况
Br J Pharmacol. 1972 Jan;44(1):117-39. doi: 10.1111/j.1476-5381.1972.tb07244.x.
10
Flashing phenomenon in blood platelets stained with fluorescent basic drugs.用荧光碱性药物染色的血小板中的闪烁现象。
Experientia. 1975 May 15;31(5):593-5. doi: 10.1007/BF01932478.