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锂对人血小板摄取5-羟色胺的长期影响。

Long-term effect of lithium on the uptake of 5-hydroxytryptamine by human platelets.

作者信息

Born G V, Grignani G, Martin K

出版信息

Br J Clin Pharmacol. 1980 Apr;9(4):321-5. doi: 10.1111/j.1365-2125.1980.tb01057.x.

DOI:10.1111/j.1365-2125.1980.tb01057.x
PMID:7378248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1429986/
Abstract

1 The content, uptake and storage of 5-hydroxytryptamine (5-HT) in platelets were determined in eight manic-depressive patients not on lithium (Li); in ten manic-depressive patients on Li; and in ten apparently normal persons as controls. 2 Platelets from the patients, whether or not on Li, contained less 5-HT than platelets from normal people. 3 5-HT uptake and storage by platelets from untreated patients were significantly lower than those of control subjects. 4 When patients had been on Li for 3 months or longer the diminished uptake and storage of 5-HT by their platelets were more than fully reversed. 5 Li added to platelet-rich plasma in vitro had no effect on the uptake of 5-HT by platelets.

摘要
  1. 测定了8名未服用锂盐（Li）的躁郁症患者、10名服用锂盐的躁郁症患者以及10名看似正常的对照者血小板中5-羟色胺（5-HT）的含量、摄取和储存情况。2. 无论是否服用锂盐，患者的血小板中5-HT含量均低于正常人的血小板。3. 未治疗患者血小板对5-HT的摄取和储存显著低于对照受试者。4. 当患者服用锂盐3个月或更长时间后，其血小板对5-HT摄取和储存的减少得到了完全逆转。5. 体外向富含血小板的血浆中添加锂盐对血小板摄取5-HT没有影响。

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1
Long-term effect of lithium on the uptake of 5-hydroxytryptamine by human platelets.锂对人血小板摄取5-羟色胺的长期影响。
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2
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本文引用的文献

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Studies on the uptake of 5-hydroxytryptamine by blood platelets.血小板对5-羟色胺摄取的研究。
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Effect of lithium on the uptake of noradrenaline by synaptosomes.锂对突触体摄取去甲肾上腺素的影响。
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Effects of the numbers and sizes of platelet aggregates on the optical density of plasma.血小板聚集体的数量和大小对血浆光密度的影响。
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Evoked release of norepinephrine and serotonin from brain slices: inhibitoon by lithium.脑片中海去甲肾上腺素和5-羟色胺的诱发释放：锂的抑制作用
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The effect of lithium chloride administration on brain and heart norepinephrine turnover rates.氯化锂给药对脑和心脏去甲肾上腺素周转率的影响。
Psychopharmacologia. 1969;14(4):315-22. doi: 10.1007/BF02190116.
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Lithium in psychiatric therapy and prophylaxis.锂在精神治疗与预防中的应用。
J Psychiatr Res. 1968 Jun;6(1):67-95. doi: 10.1016/0022-3956(68)90047-2.
9
Letter: Rapid, sensitive microassay for platelet 5HT.信函：血小板5-羟色胺的快速、灵敏微量测定法。
Thromb Diath Haemorrh. 1974 May 15;31(2):366-7.
10
Possible mechanism for biological action of lithium.锂的生物学作用的可能机制。
Nature. 1976 Dec 16;264(5587):681. doi: 10.1038/264681a0.