锂对人血小板摄取5-羟色胺的长期影响。
Long-term effect of lithium on the uptake of 5-hydroxytryptamine by human platelets.
作者信息
Born G V, Grignani G, Martin K
出版信息
Br J Clin Pharmacol. 1980 Apr;9(4):321-5. doi: 10.1111/j.1365-2125.1980.tb01057.x.
Abstract
1 The content, uptake and storage of 5-hydroxytryptamine (5-HT) in platelets were determined in eight manic-depressive patients not on lithium (Li); in ten manic-depressive patients on Li; and in ten apparently normal persons as controls. 2 Platelets from the patients, whether or not on Li, contained less 5-HT than platelets from normal people. 3 5-HT uptake and storage by platelets from untreated patients were significantly lower than those of control subjects. 4 When patients had been on Li for 3 months or longer the diminished uptake and storage of 5-HT by their platelets were more than fully reversed. 5 Li added to platelet-rich plasma in vitro had no effect on the uptake of 5-HT by platelets.
摘要
- 测定了8名未服用锂盐（Li）的躁郁症患者、10名服用锂盐的躁郁症患者以及10名看似正常的对照者血小板中5-羟色胺（5-HT）的含量、摄取和储存情况。2. 无论是否服用锂盐，患者的血小板中5-HT含量均低于正常人的血小板。3. 未治疗患者血小板对5-HT的摄取和储存显著低于对照受试者。4. 当患者服用锂盐3个月或更长时间后，其血小板对5-HT摄取和储存的减少得到了完全逆转。5. 体外向富含血小板的血浆中添加锂盐对血小板摄取5-HT没有影响。
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