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治疗浓度的阿司匹林不影响血小板对5-羟色胺的摄取。

Aspirin at therapeutic concentrations does not affect 5-hydroxytryptamine uptake by platelets.

作者信息

Drummond A H, MacIntyre D E, Olverman H J

出版信息

Br J Pharmacol. 1977 Apr;59(4):661-2. doi: 10.1111/j.1476-5381.1977.tb07735.x.

DOI:10.1111/j.1476-5381.1977.tb07735.x
PMID:858010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1667754/
Abstract

Aspirin at therapeutic concentrations does not inhibit the uptake of 5-hydroxytryptamine (5-HT) by blood platelets nor induce release of 5-HT from platelets, although platelet aggregation responses to collagen and arachidonic acid (which are dependent on platelet prostaglandin synthesis) are abolished. This does not support an earlier claim that aspirin's effects on platelet function include inhibition of 5-HT transport.

摘要

治疗浓度的阿司匹林既不抑制血小板对5-羟色胺（5-HT）的摄取，也不诱导血小板释放5-HT，尽管血小板对胶原蛋白和花生四烯酸（这两者均依赖于血小板前列腺素合成）的聚集反应被消除。这并不支持早期关于阿司匹林对血小板功能的影响包括抑制5-HT转运的说法。

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本文引用的文献

1
Aggregation of blood platelets by adenosine diphosphate and its reversal.二磷酸腺苷引起的血小板聚集及其逆转
Nature. 1962 Jun 9;194:927-9. doi: 10.1038/194927b0.
2
A simple fluorimetric microassay for adenine compounds in platelets and plasma and its application to studies on the platelet release reaction.一种用于检测血小板和血浆中腺嘌呤化合物的简单荧光微量测定法及其在血小板释放反应研究中的应用。
Biochem J. 1974 Feb;138(2):165-9. doi: 10.1042/bj1380165.
3
The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets.阿司匹林对人血小板摄取和释放5-羟色胺的影响。
Br J Pharmacol. 1976 May;57(1):149-51. doi: 10.1111/j.1476-5381.1976.tb07665.x.
4
Uptake of 5-hydroxytryptamine by rat blood platelets and its inhibition by adenosine 5'-diphosphate.大鼠血小板对5-羟色胺的摄取及其被5'-二磷酸腺苷的抑制作用。
Br J Pharmacol. 1976 Apr;56(4):417-21. doi: 10.1111/j.1476-5381.1976.tb07452.x.