孕早期贫血而非孕中期或孕晚期贫血是低出生体重的一个风险因素。

Anaemia in the first but not in the second or third trimester is a risk factor for low birth weight.

作者信息

Hämäläinen Henna, Hakkarainen Katja, Heinonen Seppo

机构信息

Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.

出版信息

Clin Nutr. 2003 Jun;22(3):271-5. doi: 10.1016/s0261-5614(02)00209-1.

DOI:10.1016/s0261-5614(02)00209-1

PMID:12765667

Abstract

OBJECTIVE

To assess pregnancy outcome in women with anaemia during pregnancy.

METHODS

The study design involved a retrospective chart review of all women registering for prenatal care in the area of Kuopio University Hospital between 1990 and 2000. A haemoglobin concentration below 100g/l was used as a cutoff for anaemia and affected women (N=597) were stratified by the trimester at which anaemia was diagnosed. Multiple regression analysis was used to compare obstetric outcomes in the study groups and in non-anaemic women (N=22,202).

RESULTS

The frequency of anaemia was 2.6%, with 0.3% occurring in the first trimester. After controlling for confounding factors, anaemia detected in the first trimester was associated with low-birth-weight infants (OR=3.14, 95% CI: 1.35-7.28) whereas the mid- and third-trimester anaemia groups showed no significantly different outcomes when compared with the non-anaemic women. First trimester anaemia was not significantly associated with small birth weight for gestational age (OR=0.98, 95% CI: 0.41-2.17) or with premature delivery <37 weeks (OR=1.80, 95% CI: 0.72-4.49).

CONCLUSIONS

Maternal anaemia detected in the first trimester is associated with low birth weight.

摘要

目的

评估孕期贫血女性的妊娠结局。

方法

本研究设计为对1990年至2000年期间在库奥皮奥大学医院地区登记进行产前检查的所有女性进行回顾性病历审查。血红蛋白浓度低于100g/l被用作贫血的临界值，受影响的女性（N = 597）按诊断出贫血的孕期进行分层。采用多元回归分析比较研究组和非贫血女性（N = 22,202）的产科结局。

结果

贫血发生率为2.6%，其中孕早期发生率为0.3%。在控制混杂因素后，孕早期检测到的贫血与低出生体重儿相关（OR = 3.14，95%CI：1.35 - 7.28），而孕中期和孕晚期贫血组与非贫血女性相比，结局无显著差异。孕早期贫血与小于胎龄儿（OR = 0.98，95%CI：0.41 - 2.17）或<37周早产（OR = 1.80，95%CI：0.72 - 4.49）无显著关联。