Trebak Mohamed, Vazquez Guillermo, Bird Gary St J, Putney James W
Laboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institute of Health, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
Cell Calcium. 2003 May-Jun;33(5-6):451-61. doi: 10.1016/s0143-4160(03)00056-3.
The mammalian transient receptor potential (TRP) proteins consist of a superfamily of Ca2+-permeant non-selective cation channels with structural similarities to Drosophila TRP. The TRP superfamily can be divided into three major families, among them the "canonical TRP" family (TRPC). The seven protein products of the mammalian TRPC family of genes (designated TRPC1-7) share in common the activation through PLC-coupled receptors and have been proposed to encode components of native store-operated channels in different cell types. In addition, the three members of the TRPC3/6/7 subfamily of TRPC channels can be activated by diacylglycerol analogs, providing a possible mechanism of activation of these channels by PLC-coupled receptors. This review summarizes the current knowledge about the mechanism of activation of the TRPC3/6/7 subfamily, as well as the potential role of these proteins as components of native Ca2+-permeant channels.
哺乳动物瞬时受体电位（TRP）蛋白由一个Ca2+通透的非选择性阳离子通道超家族组成，其结构与果蝇TRP相似。TRP超家族可分为三个主要家族，其中包括“典型TRP”家族（TRPC）。哺乳动物TRPC基因家族的七个蛋白产物（命名为TRPC1 - 7）通过与PLC偶联的受体共同激活，并且有人提出它们编码不同细胞类型中天然储存操纵通道的成分。此外，TRPC通道的TRPC3/6/7亚家族的三个成员可被二酰基甘油类似物激活，这为PLC偶联受体激活这些通道提供了一种可能的机制。本综述总结了目前关于TRPC3/6/7亚家族激活机制的知识，以及这些蛋白作为天然Ca2+通透通道成分的潜在作用。
