Strassnig Martin, Brar Jaspreet Singh, Ganguli Rohan
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213-2593, USA.
Schizophr Res. 2003 Jul 1;62(1-2):73-6. doi: 10.1016/s0920-9964(02)00441-3.
To examine the associations between sociodemographic variables, body weight and quality of life in schizophrenic outpatients.
Assessments included an interview to obtain sociodemographic data, administration of a Quality of Life questionnaire (the MOS SF-36) and measurement of height and weight. Body mass index was calculated (kg/m(2)). SF-36 subscores were examined for statistical differences based on BMI categories: healthy weight (BMI<or=24.9), overweight (BMI 25-29.9) and obese (BMI>or=30). Correlations with sociodemographic variables were also examined.
Body weight was inversely correlated (level p<or=0.005) to the SF-36 items: physical functioning (PF, -0.452), role limitations due to physical functioning (-0.279), role limitations due to emotional functioning (-0.256), vitality (-0.200), general health (GH, -0.367) and physical component score (PCS, -0.400). Mental component score (MCS) was not significantly correlated to body weight. When comparing quality of life across BMI categories, obese subjects had worse physical functioning (p<or=0.0005) and general health (p<or=0.005), reported more role limitations due to emotional functioning (p<or=0.05) and a lower physical component score (p<or=0.005). Mental component score was not significantly influenced by BMI.
Quality of life in schizophrenic patients is related to body weight. The burden of obesity is primarily experienced as a physical problem.
研究精神分裂症门诊患者的社会人口统计学变量、体重与生活质量之间的关联。
评估内容包括通过访谈获取社会人口统计学数据、发放生活质量问卷（医学结局研究简表36，即MOS SF - 36）以及测量身高和体重。计算体重指数（kg/m²）。根据体重指数类别：健康体重（体重指数≤24.9）、超重（体重指数25 - 29.9）和肥胖（体重指数≥30），对MOS SF - 36的子分数进行统计学差异检验。同时也研究了与社会人口统计学变量的相关性。
体重与MOS SF - 36的各项指标呈负相关（p≤0.005水平）：生理功能（PF，-0.452）、因生理功能导致的角色受限（-0.279）、因情感功能导致的角色受限（-0.256）、活力（-0.200）、总体健康（GH，-0.367）和生理健康总分（PCS，-0.400）。心理健康总分（MCS）与体重无显著相关性。比较不同体重指数类别的生活质量时，肥胖患者的生理功能更差（p≤0.0005），总体健康状况更差（p≤0.005），因情感功能导致的角色受限更多（p≤0.05），生理健康总分更低（p≤0.005）。心理健康总分不受体重指数的显著影响。
精神分裂症患者的生活质量与体重有关。肥胖的负担主要表现为身体问题。
