Chance Steven A, Esiri Margaret M, Crow Timothy J
University of Oxford, Oxford, UK.
Schizophr Res. 2003 Jul 1;62(1-2):123-31. doi: 10.1016/s0920-9964(02)00344-4.
The anatomical origin of the enlargement of the cerebral ventricles in schizophrenia is obscure.
In this study, the volumes of the hemispheres and lateral ventricles were assessed in MRI scans of 43 formalin-fixed brains (23 from patients and 19 comparison subjects) using a spline 'snake' segmentation method.
A bilateral ventricular volume increase was found in schizophrenia. Whereas enlargement of the lateral ventricle (mean: 54%) as a whole was related to age of onset and was greater in females than in males, enlargement of the temporal horn (mean: 54%) was not strongly related to age of onset or sex. Lateral ventricle volume was negatively correlated with STG, fusiform and parahippocampal volume in schizophrenia. Hemispheric volumes were unchanged.
The differing correlates of the components of ventricular enlargement suggest a degree of selectivity of the disease process with a focus in the temporal lobe.
精神分裂症患者脑室扩大的解剖学起源尚不清楚。
在本研究中，使用样条“蛇形”分割法对43例福尔马林固定脑（23例来自患者，19例为对照对象）的MRI扫描图像进行半球和侧脑室体积评估。
在精神分裂症患者中发现双侧脑室体积增加。虽然侧脑室整体扩大（平均：54%）与发病年龄有关，且女性大于男性，但颞角扩大（平均：54%）与发病年龄或性别无强烈关联。在精神分裂症中，侧脑室体积与颞上回、梭状回和海马旁回体积呈负相关。半球体积无变化。
脑室扩大各组成部分的不同相关性表明疾病过程存在一定程度的选择性，且以颞叶为重点。
