Debol Steven M, Stanley Michael W, Mallery Shawn, Sawinski Elizabeth, Bardales Ricardo H
Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA.
Diagn Cytopathol. 2003 Jun;28(6):316-21. doi: 10.1002/dc.10294.
The glomus tumor is usually a benign solitary neoplasm that arises from modified smooth muscle cells of the glomus body, a type of neuromyoarterial receptor that plays a role in the regulation of arterial blood flow. We report a case of gastric glomus tumor diagnosed by endoscopic ultrasound-guided fine-needle aspiration. Smears exhibited groups of cohesive, uniform, small, round to polygonal cells with scant cytoplasm, indistinct cell borders, and round, hyperchromatic nuclei with homogeneous chromatin. The cell block contained fragments of cells with similar morphologic features and immunohistochemical staining exhibited positivity for smooth muscle actin and vimentin. The diagnosis was confirmed by the surgically resected specimen. Ultrastructural examination revealed prominent pinocytotic vesicles lining the plasmalemma. In this report, we discuss the differential diagnosis of gastric glomus tumor and compare the cytologic features of this case with two others reported in the literature.
血管球瘤通常是一种良性孤立性肿瘤，起源于血管球的改良平滑肌细胞，血管球是一种神经肌动脉感受器，在调节动脉血流中起作用。我们报告一例经内镜超声引导下细针穿刺活检诊断的胃血管球瘤病例。涂片显示有一群群相互黏附、形态一致、小的圆形至多边形细胞，胞质稀少，细胞边界不清，细胞核圆形、深染，染色质均匀。细胞块包含具有相似形态特征的细胞碎片，免疫组化染色显示平滑肌肌动蛋白和波形蛋白呈阳性。手术切除标本证实了诊断。超微结构检查显示质膜内衬有明显的胞饮小泡。在本报告中，我们讨论了胃血管球瘤的鉴别诊断，并将该病例的细胞学特征与文献中报道的其他两例进行了比较。
