Riha Karel, Shippen Dorothy E
Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, Texas 77843-2128, USA.
Chromosome Res. 2003;11(3):263-75. doi: 10.1023/a:1022892010878.
The stability of eukaryotic genomes is provided in part by the integrity of telomeres, the nucleoprotein caps on the ends of chromosome. Recent studies reveal that proper telomere architecture is required for long-term proliferation capacity. Here we describe molecular mechanisms that protect and maintain chromosome ends and discuss why Arabidopsis is emerging as a powerful new model for elucidating fundamental aspects of telomere biology.
真核生物基因组的稳定性部分由端粒的完整性提供,端粒是染色体末端的核蛋白帽。最近的研究表明,适当的端粒结构是长期增殖能力所必需的。在这里,我们描述了保护和维持染色体末端的分子机制,并讨论了为什么拟南芥正在成为阐明端粒生物学基本方面的强大新模型。