Müller Stefan, Tirapelli Carlos R, de Oliveira Ana M, Murillo Renato, Castro Victor, Merfort Irmgard
Institute of Pharmaceutical Biology, University Freiburg, Stefan-Meier-Str. 19, 79104 Freiburg, Germany.
Phytochemistry. 2003 Jun;63(4):391-6. doi: 10.1016/s0031-9422(03)00073-6.
From the aerial parts of Oyedaea verbesinoides nine ent-kauranes and a sesquiterpene were isolated. ent-9alpha-Hydroxy-kaur-16-en-19-oic acid, ent-15beta-tigloyloxy-9alpha-hydroxy-kaur-16-en-19-oic acid, ent-15beta-angeloyloxy-9alpha-hydroxy-kaur-16-en-19-oic acid, ent-16alpha-hydroxykaurane and 1alpha-angeloyloxy-carotol are new for the genus or the species and ent-15beta-angeloyloxy-7alpha,9alpha-dihydroxy-kaur-16-en-19-oic acid is reported for the first time. Structure elucidation was based on one and two dimensional NMR as well as ESI and CI-MS analysis. Some diterpenes were proven to exhibit inhibitory effects on smooth muscle contraction on rat aorta.
