共济失调患者中抗麦醇溶蛋白抗体的患病率。

Prevalence of antigliadin antibodies in ataxia patients.

作者信息

Abele M, Schöls L, Schwartz S, Klockgether T

机构信息

Department of Neurology, University of Bonn, Germany.

出版信息

Neurology. 2003 May 27;60(10):1674-5. doi: 10.1212/01.wnl.0000069606.82919.04.

DOI:10.1212/01.wnl.0000069606.82919.04

PMID:12771263

Abstract

We determined antigliadin antibodies in 95 ataxia patients and 73 controls. Antibodies were positive in 8% of the controls, 19% of patients with sporadic ataxia, 8% of patients with recessive ataxia, and 15% of patients with dominant ataxia. Statistical comparison using chi(2) statistics did not reveal significant differences between the groups. Although we found a trend toward a higher prevalence of antigliadin antibodies in patients with sporadic ataxia and dominant ataxia, our data do not support an association of ataxia with antigliadin antibodies.

摘要

我们检测了95例共济失调患者和73名对照者的抗麦醇溶蛋白抗体。对照组中8%的人抗体呈阳性，散发性共济失调患者中19%呈阳性，隐性共济失调患者中8%呈阳性，显性共济失调患者中15%呈阳性。使用卡方统计进行的统计学比较未显示出各组之间存在显著差异。尽管我们发现散发性共济失调和显性共济失调患者中抗麦醇溶蛋白抗体的患病率有升高趋势，但我们的数据并不支持共济失调与抗麦醇溶蛋白抗体之间存在关联。