醋酸卡泊芬净成功治疗克柔念珠菌感染：一种新型抗真菌药物。
Successful treatment of Candida krusei infection with caspofungin acetate: a new antifungal agent.
作者信息
McGee William T, Tereso Gary J
机构信息
Department of ICU Quality Improvement, Baystate Medical Center, Springfield, MA 01199, USA.
出版信息
Crit Care Med. 2003 May;31(5):1577-8. doi: 10.1097/01.CCM.0000063145.15336.31.
OBJECTIVE
Systemic fungal infections have high mortality, and therapy is often toxic. Caspofungin acetate, a new antifungal agent with minimal toxicity, may provide a better alternative to typical therapy for Candida krusei.
DESIGN
Case report.
SETTING
Multidisciplinary intensive care unit (ICU) of a community teaching hospital.
PATIENT
A 22-yr-old male with acute lymphoblastic leukemia and Candida krusei fungemia failed therapy with fluconazole and amphotericin B.
INTERVENTIONS
Caspofungin acetate given intravenously as a 70-mg loading dose, followed up by 50 mg daily along with standard ICU care.
RESULTS
Survival without toxicity from therapy.
CONCLUSION
Efficacy of caspofungin acetate in a patient with life-threatening Candida Krusei infection.
目的
系统性真菌感染死亡率高，且治疗往往具有毒性。醋酸卡泊芬净是一种毒性极小的新型抗真菌药物，可能为克鲁斯念珠菌的典型治疗提供更好的替代方案。
设计
病例报告。
地点
社区教学医院的多学科重症监护病房（ICU）。
患者
一名22岁男性，患有急性淋巴细胞白血病和克鲁斯念珠菌血症，氟康唑和两性霉素B治疗失败。
干预措施
静脉注射醋酸卡泊芬净，负荷剂量70mg，随后每日50mg，同时给予标准ICU护理。
结果
治疗后存活且无毒性。
结论
醋酸卡泊芬净对危及生命的克鲁斯念珠菌感染患者有效。
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